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- John Bailey '64, Cinematographer
- Chemin Sylvia Bernard '80, Casting Director
- Melissa Blake '95, Writer and producer, "Sleepy Hollow"
- Effie Brown '93, Filmmaker
- Francie Calfo '89, President, Imagine Television
- Claudine Cazian '00, Radio Producer, Ryan Seacreast Show
- Stan Chambers '43, TV News Reporter
- Brian Helgeland M.A. '87, Director and Screenwriter, "42"
- Jovana Lara-Brooks '88, ABC7 News Reporter
- Francis Lawrence '91, Director, "Hunger Games: Catching Fire"
- Tom Leach '08, TV producer and founder, Red Media
- Kate Micucci '03, Musician, Comedian and Actress, "Garfunkel and Oates"
- David Mirkin '78, Producer and Writer, "The Simpsons"
- Gail Mitchell '75, Senior Editor, Billboard Magazine
- Kathy Nielsen '76, Senior Vice President, Columbia TriStar
- Van Partible '93, writer and creator, "Johnny Bravo"
- Tony Plana '75, Actor and Director
- M.L. Snowden '74, Sculptor
- William L. Strickland '71, Sports Agent
- James Wong '83, Writer, Director, Producer, "American Horror Story"
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- Tom Aaker '84, CEO, Standard Chartered Bank Indonesia
- Billy Bean '86, Former Major League Baseball Player, Motivational Speaker
- Rhonda Bethea '93, General Counsel, Bank of America
- Mitch Butier '93, CFO, Avery Dennison Corp.
- Alex Martin Chaves '86, CEO, Parking Company of America
- Tim Dean '82, Entrepreneur
- Martha De La Torre '78, Publisher and Entrepreneur
- R. Chad Dreier '69, President, Chair, CEO, Ryland Group
- Henry Jordan '78, CEO and Chairman, Wells Fargo Capital Finance
- Bob Kerslake '58, Chairman Emeritus, Marshall & Stevens
- Dr. Edison H. Miyawaki '52, Co-Owner, Cincinnati Bengals and Reds
- Kathy Nielsen '76, Senior Vice President, Columbia TriStar
- Steve Page '62, Law '68, CFO, United Technologies
- Shira Shafir '99, Director of Social Innovation and Impact, TOMS
- Dr. Bob Sclabassi '62, Doctor and Entrepreneur
- Stuart Shoen '02, Executive Vice President, U-Haul
- Christopher Silva '86, Law '89, CEO, St. Francis Vineyards and Winery
- Renata Simril '93, Senior Vice President of External Affairs, Dodgers
- John Stankey '85, Chief Strategy Officer, AT&T
- Rosemary Turner '84, President, UPS Chesapeake District
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- Kevin Baxter M.A. '01, Educator and Superintendent, Los Angeles Archdiocese
- Lawrence Bobo '79, Professor, Harvard University
- Michael Engh, S.J. '72, President, Santa Clara University
- Diana Fuentes-Michel '79, Educator
- Dr. James Herndon '61, Doctor and Professor, Harvard University
- Karina Moreno '01 M.A. '03, Educator and Princial, Dolores Mission Elementary School
- Albert Raboteau '64, Henry W. Putnam Professor of Religion Emeritus, Princeton University
- Dr. Ricardo Romo, M.A. '70, President, University of Texas, San Antonio
- James Walker '58, M.A. '60, Educator
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- Dr. Christian de Virgilio '82, Surgeon and Educator
- Dr. James Herndon '61, Doctor and Professor, Harvard University
- Dr. Leo Lagasse '52, Cancer Surgeon and Humanitarian
- Dr. Edison H. Miyawaki '52, President, Chairman and CEO of Family Health I and II
- Dr. Bob Sclabassi '62, Doctor and Entrepreneur
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- Hon. Irma J. Brown '70, Law '73, Superior Court Justice
- Olegario D. Cantos VII '92, Law '97, Attorney, U.S. Department of Justice
- Bill Campbell '65, Orange County Supervisor
- Hon. Victor Chavez '53, Law '59, Civil Court Justice
- Hon. Carol Codrington '81, Law '84, Superior Court Justice
- Tony Coelho '64, Former U.S. Representative
- Gabriella Gomez '95, Assistant Secretary, U.S. Department of Education
- Rudy deLeon '74, Former Deputy Secretary, U.S. Department of Defense
- Michael Lawson '75, Lawyer and Humanitarian
- Jon Peters '85, Captain, Los Angeles Police Department
- Mike Steed '71, Law '74, Lawyer and Philanthropist
- J. Steven Rhodes '73, Former U.S. Ambassador
- David Roberti '61, Former State Senator and Assemblyman
- Fred Taugher '61, Consultant and Lobbyist
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- Gregory Boyle, S.J., M.A. '85, Founder, Homeboy Industries
- Harold Brooks '70, CEO, American Red Cross, San Francisco
- Tony Brown '92, Executive Director, HOLA
- Maria Dzida '74, M.A. '95, Director, Soup Kitchen
- J.D. Hokoyama '67, M.Ed. '75, Co-founder and President of Leadership Education for Asian Pacific Islanders
- Dr. Leo Legasse '52, Cancer Surgeon and Humanitarian
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- Gregory Boyle, S.J., M.A. '85, Founder, Homeboy Industries
- Michael Engh, S.J. '72, President, Santa Clara University
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- Tom Mueller M.S. '92, Rocket Engine Designer, SpaceX
- Tim Psomas '62, Engineer and Chairman of Psomas Engineering
- Jim Stahl '65, Engineer, National Academy of Engineering